Philippine Health Research Registry
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Results 1 - 20 of 264 research(es) under NUHRA Regime 2010 - 2016, Health Technology Development, Drug Discovery and Development

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Study
         
Project Status:
Ongoing
Project Description:
The project aims to show that anti-TAG72 immunoliposomes specifically bind then kill TAG72-expressing cells. The immunoliposomes are synthesized from commercial reagents (Dr. Sabido, Project 2). They are then loaded with Doxorubicin. A humanized anti-TAG72 antibody, hCC49 (Dr. Bascos, Project 1), is then attached to the liposome. The amount of ra... [read more]
Project Status:
Ongoing
Project Description:
The aim of this trial is to assess the efficacy of the CYD dengue vaccine in preventing symptomatic, virologically-confirmed dengue cases
Project Status:
Ongoing
Project Description:
Solifenacin succinate as a tablet formulation is already on the market for the treatment of symptoms of overactive bladder in adults. For the use in children and adolescent patients a new formulation of solifenacin has been developed. This study will investigate the effect and safety of solifenacin suspension compared to a non-active drug (placebo... [read more]
Project Status:
Ongoing
Project Description:
This is a 40-week study to investigate how safe and effective solifenacin solution is in treating children/adolescents with symptoms of overactive bladder (OAB) who completed study 905-CL-076. To measure the efficacy of the treatment the patient will complete a 7-day patient diary prior to every visit, starting at Visit 9. The patient will attend t... [read more]
Project Status:
Ongoing
Project Description:
Isolation and identification of the anti-inflammatory constituent/s from M. oleifera is a two-pronged project that may lead to lead compounds that can be developed into an anti-inflammatory drug and/or herbal product that is chemically standardized.
Project Status:
Ongoing
Project Description:
This project is part of the first phase of a program which ultimately aims to produce herbal preparations or pure therapeutic drug leads sourced out from medicinal plants found in Mindanao. The first phase of this program is exploratory and holistic in nature in the sense that all plant extracts will be subjected to genera... [read more]
Project Status:
Completed
Project Description:
This project is a component of the UP Manila Complementary and Traditional Medicine Program. It shall address the need to document the healing traditions of the Mangyans (Alangan) people as well as to actively search for potentially useful pharmacologic agents from the Mangyan (Alangan) folklore. At the same time, the project will conduct appropria... [read more]
Project Status:
Ongoing
Project Description:
The project is part of the program DOST OL Traps in Schools Nationwide and implemented in collaboration with DOST Regional Offices, Industrial Technology Development Institute, Science and Technology Information Institute, Department of Education, Department of Health and local government units. DOST developed ovilarvicidal traps are installed i... [read more]
Project Status:
Completed
Project Description:
Preparation of doxorubicin-loaded immunoliposome for breast cancer
Project Status:
Ongoing
Project Description:
The study is conducted to evaluate efficacy and safety of a combined oral contraceptive of estradiol valerate and dienogest in the treatment of heavy menstrual bleeding
Project Status:
Completed
Project Description:
SP0994 is a Phase 3, multicenter, double-blind, follow-up study evaluating the long-term safety of lacosamide (LCM) (200 to 600mg/day) compared with carbamazepine (controlled release) (CBZ-CR) (400 to 1200mg/day), used as monotherapy in subjects ≥16 years of age with partial-onset or generalized tonic-clonic seizures coming from the SP0993 study.
Project Status:
Ongoing
Project Description:
The research project 's main objective is to isolate a compound from Moringa oleifera leaves with acceptable immunotherapeutic index, either as immunostimulant or immunosuppressant. Immunobioassays are used during the sequential isolation of the compound.
Project Status:
Ongoing
Project Description:
A Multicenter, Double-Blind, Randomized, Parallel-Group, Phase III Study to Compare the Efficacy and Safety of Hercules Versus Herceptin® in Patients with HER2+Metastatic Breast Cancer. Primary objective is to compare the effect of Hercules vs. Herceptin on the over-all tumor response, both in combination with docetaxel, in patients with HER2+ met... [read more]
Project Status:
Completed
Project Description:
This study involves patients with acute exacerbation of schizoprenia
Project Status:
Completed
Project Description:
This is a randomized, placebo-controlled, initial open-label (with placebo-matched dosing), doubleblind, multi-center, multi-national trial evaluating the efficacy and safety of sublingually (SL) administered asenapine compared with placebo in the prevention of recurrent mood episodes in subjects with bipolar I disorder suffering from an acute mani... [read more]
Project Status:
Completed
Project Description:
Phase 3, multicenter, randomized, double-blind, placebocontrolled, parallel-group, outpatient study examining the effect of LY2127399 120 mg Q4W and 120 mg Q2W versus placebo in patients with active SLE who may be receiving concomitant SoC.
Project Status:
Completed
Project Description:
Study H9B-MC-BCDX (BCDX) is an open-label extension (OLE) study that assesses the longterm safety and efficacy of LY2127399 in patients with SLE who may be receiving concurrent standard of care (SoC) from 2 double-blind, Phase 3 Studies H9B-MC-BCDS (BCDS) and H9BMC- BCDT (BCDT).
Project Status:
Completed
Project Description:
Bimatoprost Preservative-Free (PF) Intracameral (IC) Drug Delivery System (DDS) (sustained-release biodegradable implants containing preservative-free AGN-192024 [bimatoprost])
Project Status:
Terminated
Project Description:
This study is being conducted to establish the potential role of bimatoprost 0.03% PF in the management of paediatric glaucoma. The intent of this paediatric investigation is to evaluate the safety and efficacy of bimatoprost in the management of glaucoma in paediatric patients in whom surgical intervention is not indicated or anticipated for IOP l... [read more]
Project Status:
Completed
Project Description:
HGS1006-C1115 evaluating the efficacy and safety of belimumab administered subcutaneously (SC) in patients with active, autoantibody-positive systemic lupus erythematosus (SLE).