Philippine Health Research Registry
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Results 1 - 20 of 20 research(es) under NUHRA Regime 2010 - 2016, Health Technology Development, Genomics/Molecular Technology

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Study
         
Project Status:
Ongoing
Project Description:
A web-based interactive genome library will be constructed for surveillance, detection, characterization, genotyping, and genotype and drug-resistance monitoring of influenza virus infection in the Philippines. This one-stop-shop portal will contain relevant and up-to-date information about S-OIV A (H1N1), its current status and management in the P... [read more]
Project Status:
Ongoing
Project Description:
To determine the diurnal BP patterns of Filipino hypertensive patients using the 24 hour ambulatory BP monitor (ABPM).
Project Status:
Ongoing
Project Description:
Schistosomes, the causative agent of schistosomiasis, are among the most significant parasites of humans in the developing world. Schistosomiasis ranks second to malaria in public health importance. This study aims to determine strain differences among geographic isolates of Schistosoma japonicum and Oncomelania hupensis quadrasi collected from 15 ... [read more]
Project Status:
Completed
Project Description:
Y-chromosomal DNA typing is the most powerful tool in male identification as it selectively amplifies the male DNA from any given sample mixture. However, limitations for the current set of usable Y-DNA markers include not being able to differentiate closely-related male individuals since the Y-chromosome, in principle, is passed and conserved thro... [read more]
Project Status:
Ongoing
Project Description:
Breast cancer is the most common malignancy among women worldwide (IARC, 2008). It has an estimated 1.38 million new cases diagnosed in 2008 (IARC). In the Philippines, there has been an observed steady rise in the incidence of the disease with an age-standardized rate of 31.9 per 100,000 women and an estimated national age-standardized mortality r... [read more]
Project Status:
Ongoing
Project Description:
In cases of disaster victim identification, missing persons and other forensic investigations involving human remains identification, samples encountered may have been exposed to various environmental conditions such as extreme heat, water immersion, burial, chemical treatments and post mortem decomposition. Such conditions can cause significant da... [read more]
Project Status:
Ongoing
Project Description:
DNA technology is the most powerful scientific tool for human identification. DNA profiling of biological samples such as tissues, e.g. bones, muscles; and body fluids such as blood, saliva, sweat and urine, is used to determine the human sources of these samples. In the present study, we propose to use this same technology to generate the autosoma... [read more]
Project Status:
Completed
Project Description:
Male-specific polymorphisms on the non-recombining portion of the Y-chromosome, specifically Short Tandem Repeat DNA (Y-STR DNA) markers, have become an important tool for forensic investigations. In the Philippines, currently available Y-STR sets (9-12 Y-STR DNA markers) are used in deficient paternity testing cases; in the detection of male DNA i... [read more]
Project Status:
Ongoing
Project Description:
There is paucity of data regarding the genetic basis for hearing impairment among Filipinos. Though local prevalence of hearing impairment has been established at 1.4 per 1000 live births the proportion of those with genetic basis is yet unknown this has been pegged at 50% in most reports. GJB2 is the most common cause of non-syndromic hearing loss... [read more]
Project Status:
Ongoing
Project Description:
The project aims to arrive at clinically meaningful signature marker and local molecular databases for leptospirosis in the Philippines. By analyzing more than 47,000 gene products and splice variants, and comparing cases with mild manifestations to those with more serious sequelae, a set of more meaningful molecular signatures can be derived to pr... [read more]
Project Status:
Ongoing
Project Description:
The project aims to arrive at clinically meaningful molecular signatures and local databases for sepsis in the Philippines. By analyzing more than 47,000 gene products and splice variants, and comparing complicated cases to uneventful ones, a set of more meaningful markers can be derived to prognosticate diseases. And by comparing patients with sep... [read more]
Project Status:
Ongoing
Project Description:
The project aims to arrive at clinically meaningful transcriptional biomarkers and molecular pathways, as well as to establish corresponding local reference databases, for T2DM and its complications in the Philippines. In effect, it seeks to further add up to the global initiatives that can contribute to the furtherance of efforts that seeks to di... [read more]
Project Status:
Ongoing
Project Description:
Microarray screning of genetic markers associated with SLE in Filipinos
Project Status:
Ongoing
Project Description:
The project aims to identify the association of known candidate genetic variations with effective drug response and the occurrence of adverse drug events to medications for the treatment of hypertension, dyslipidemia, and/or coronary artery disease.... [read more]
Project Status:
Ongoing
Project Description:
The project aims to identify the prevalence of candidate genetic variations associated with hypertension, dyslipidemia and coronary artery disease among Filipinos.
Project Status:
Ongoing
Project Description:
The study is a collaborative project of the Department of Health Research Institute for Tropical Medicine, Wellcome Trust Sanger Institute, UK, and the WHO Collaborating Center for Antimicrobial Resistance, USA which aims to establish local capacity for whole genome sequencing to enhance pathogen surveillance within the Philippines. Results of the... [read more]
Project Status:
Ongoing
Project Description:
Dengue is the most important arthropod-borne disease of humans and endemic in the Philippines which has the 4th largest disease burden of all Southeast Asian countries. Dengue hemorrhagic fever (DHF) epidemics occur at least every 2-3 years in the Philippines. Despite national efforts to reduce the disease burden, cases continue to rise, with ov... [read more]
Project Status:
Completed
Project Description:
In criminal investigations, crime scenes are processed to collect evidence that can be used to link the victim to the perpetrator, perpetrator to the scene, witnesses to the scene, and various objects to the crime. DNA profiling is one type of analysis performed on these pieces of evidence in order to determine whether or not the evidentiary materi... [read more]
Project Status:
Ongoing
Project Description:
This research is a multidisciplinary program that aims to study the palaeohistory of Mindoro Island. The program is composed of multiple projects that focus on specialized fields such as archaeology, geology, marine biogeography, genetics, and anthropology, all of which will contribute to the reconstruction of prehistoric Mindoro. The genetics comp... [read more]
Project Status:
Completed
Project Description:
With the increasing number of reported cases of sexual assault in the Philippines, there is an urgent need for the routine incorporation of DNA evidence in criminal investigations to aid in the objective identification of offenders. To address the current absence of national guidelines for forensic DNA analysis, existing laboratory procedures were ... [read more]