Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Mangoes (Mangifera indica L. cv. ‘Carabao’) in Selected Provinces in the Philippines
PHRR190125-001936
Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides from Mangoes (Mangifera indica L. cv. ‘Carabao’) in Selected Provinces in the Philippines
There has been numerous research studies conducted using the mango fruit and its parts due to its large potential for medicinal purposes especially its pythochemical and pharmacological activities. The different parts of the fruits have antidiabetic, anti-inflammatory, antifungal, antihelmic, antiparasitic, antitumor, antibone, anti HIV, resorption, antipyretic, antispasmodic, antiallergic, immunomodulation, hypolipidemic, gastoprotective, hepatoprotective properties, among others. Due to the aforementioned medicinal and health potentials of the mango fruit, it is necessary to study the different biomolecules (especially proteins) that may contribute to the health beneficial claims of the mango fruit. Proteins are needed by the body as source of amino acids. Upon digestion, these proteins are subjected to different digestive enzymes and converted to either amino acids or small peptides. These small peptides maybe responsible for the many medicinal properties and need to be studied further to know its specific effects in the body. These small peptides are better known as bioactive peptides. They are protein fragments that are initially inactive but shows physiological function once cleaved from the parent protein. They are found to have function in preventing and treating life-style related diseases such as hypertension, cardiovascular disease, cancers, osteoporosis, stress and obesity. The most extensively studied bioactive peptides are the antihypertensive peptides, particularly those which inhibit angiotensin I converting enzyme (ACE) which is associated with the regulation of blood pressure in the body. Inhibition of the ACE will result in an antihypertensive effect. Hypertension is recorded to be one of the most frequent causes of deaths in the world. An alarming statistics of seven (7) million deaths every year are caused by high blood pressure and 1.5 billion people are suffering from its complications (WHO, 2014). Meanwhile, here in the Philippines, 21% or approximately 10 million Filipino adults suffer from this disease (Philippine Society of Hypertension, 2008). With the high incidence of hypertension in the Philippines, it is important to look for natural alternative sources of anti-hypertensive drugs that tend to have fewer side effects compared with synthetic drugs.
| Regime | Classification | Priority |
|---|---|---|
| 2017 - 2022 | Global competitiveness and innovation in health | Functional foods |
| Start Date | Duration in Months | Target Completion Date | Actual Completion Date |
|---|---|---|---|
| 2018-11-16 | 12 | 2019-11-16 | 0000-00-00 |
Ongoing
| Institution | Classification | Region | LTO # |
|---|---|---|---|
| University Of The Philippines - Los Banos | Public Higher Education Institution - State Universities and Colleges | Region IV-A |
| Institution | Classification | Region | LTO # |
|---|---|---|---|
| University of the Philippines - Los Baños, College of Veterinary Medicine | Public Higher Education Institution - State Universities and Colleges | Region IV-A |
| Institution | Region |
|---|---|
| Philippine Council for Health Research and Development, Department of Science and Technology | NCR |
| Name | Institution and Institution Address | |
|---|---|---|
| Dr. Mary Ann O. Torio | motorio@up.edu.ph | N/A |
| Name | Institution and Institution Address | |
|---|---|---|
| Dr. Mary Ann O. Torio | motorio@up.edu.ph | N/A |
| Name | Expertise | Affiliation |
|---|---|---|
| Maria Amelita C. Estacio | Immunohistochemistry, Rodent Stereotaxic Surgery, Behavioral Testing, Toxicity Tests | University of the Philippines - Los Baños, College of Veterinary Medicine |
Hypertension
In vitro analyses and in vivo efficacy studies, the purified protein(s) and peptide(s) from 'Carabao' Mango from Batangas, Zambales, Guimaras, and Zamboanga will be characterized in terms of anti-ACE activity. The result will enhance the characteristics of mango fruit as a functional food.
Unspecified
Completed
- Philippines
Non-clinical Studies