A randomized, double-blind, controlled study on the safety and efficacy of 25% Tinospora rumphii (Makabuhay) cream versus 2% mupirocin cream on superficial pyodermas caused by Staphylococcus aureus
PHRR191025-002228
A randomized, double-blind, controlled study on the safety and efficacy of 25% Tinospora rumphii (Makabuhay) cream versus 2% mupirocin cream on superficial pyodermas caused by Staphylococcus aureus
This study determined the safety and efficacy of 25% Tinospora rumphii cream versus 2% mupirocin cream in the treatment of superficial pyodermas caused by S. aureus. A randomized, double-blind, controlled studyof 60 patients with superficial pyodermas caused by S aureus, aged 18-60, was given either 25% Tinospora rumphii or 2% mupirocin cream for two weeks. Bactericidal activity, erythema, edema, induration and size of lesion were evaluated at baseline, Days 3, 7, and 14. Particiant’s Global Assessment score and adverse events were noted. Statistical analysis was done using Mann-Whitney U test.
| Regime | Classification | Priority |
|---|---|---|
| 2017 - 2022 | Global competitiveness and innovation in health | Drug discovery and development |
| Start Date | Duration in Months | Target Completion Date | Actual Completion Date |
|---|---|---|---|
| 2017-04-01 | 8 | 2017-12-01 | 2018-12-18 |
Completed
| Institution | Classification | Region | LTO # |
|---|---|---|---|
| Research Institute for Tropical Medicine | Government | NCR |
| Institution | Classification | Region | LTO # |
|---|---|---|---|
| Self-funded | None | None |
| Institution | Region |
|---|---|
| Self-funded | None |
| Name | Institution and Institution Address | |
|---|---|---|
| Grace Monica Ibaviosa | dermatologyritm@gmail.com | Research Institute for Tropical Medicine, Alabang, Muntinlupa City |
| Name | Institution and Institution Address | |
|---|---|---|
| Grace Monica Ibaviosa | dermatologyritm@gmail.com | Research Institute for Tropical Medicine, Alabang, Muntinlupa City |
| Name | Expertise | Affiliation |
|---|---|---|
| Grace Monica P. Ibaviosa, MD | Dermatology | Research Institute for Tropical Medicine |
| Johannes F. Dayrit, MD, FPDS | Dermatology | Research Institute for Tropical Medicine |
| Ma. Teresita G. Gabriel, MD, FPDS | Dermatology | Research Institute for Tropical Medicine |
Staphylococcal Infections
Cutaneous Bacterial Infections
Alternative Medicine
Safety and Efficacy of 25% Tinospora rumphii cream vs 2% Mupirocin cream in the treatment of superficial pyodermas caused by S aureus
To compare the bactericidal activity of 25% Tinospora rumphiicream and 2% mupirocin cream based on the percentage of patients bacteriologically cured at day 14 of treatment
To compare the efficacy of 25% Tinospora rumphii cream and 2% mupirocin cream based on the clinical efficacy grading scale of erythema, edema, induration and size of lesions at baseline, days 3, 7 and 14 of treatmentby having a 2 point scale improvement at the end of the treatment period
To compare the Participants Global Assessment score in the 25% Tinospora rumphii cream and 2% mupirocin cream using a 7 point scale at days 3, 7, and 14 of treatment
To compare the occurrence and severity of adverse cutaneous reactions in the 25% Tinospora rumphiicream and 2% mupirocin treatment groups using a 4 point scale on days 3, 7 and 14 of treatment
Completed
Non-clinical Studies