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A randomized, double-blind, controlled study on the safety and efficacy of 25% Tinospora rumphii (Makabuhay) cream versus 2% mupirocin cream on superficial pyodermas caused by Staphylococcus aureus

PHRR191025-002228

A randomized, double-blind, controlled study on the safety and efficacy of 25% Tinospora rumphii (Makabuhay) cream versus 2% mupirocin cream on superficial pyodermas caused by Staphylococcus aureus

This study determined the safety and efficacy of 25% Tinospora rumphii cream versus 2% mupirocin cream in the treatment of superficial pyodermas caused by S. aureus. A randomized, double-blind, controlled studyof 60 patients with superficial pyodermas caused by S aureus, aged 18-60, was given either 25% Tinospora rumphii or 2% mupirocin cream for two weeks. Bactericidal activity, erythema, edema, induration and size of lesion were evaluated at baseline, Days 3, 7, and 14. Particiant’s Global Assessment score and adverse events were noted. Statistical analysis was done using Mann-Whitney U test.

Regime Classification Priority
2017 - 2022 Global competitiveness and innovation in health Drug discovery and development
Start Date Duration in Months Target Completion Date Actual Completion Date
2017-04-01 8 2017-12-01 2018-12-18

Completed

Institution Classification Region LTO #
Research Institute for Tropical Medicine Government NCR
Institution Classification Region LTO #
Self-funded None None
Institution Region
Self-funded None
Name E-Mail Institution and Institution Address
Grace Monica Ibaviosa dermatologyritm@gmail.com Research Institute for Tropical Medicine, Alabang, Muntinlupa City
Name E-Mail Institution and Institution Address
Grace Monica Ibaviosa dermatologyritm@gmail.com Research Institute for Tropical Medicine, Alabang, Muntinlupa City
Name Expertise Affiliation
Grace Monica P. Ibaviosa, MD Dermatology Research Institute for Tropical Medicine
Johannes F. Dayrit, MD, FPDS Dermatology Research Institute for Tropical Medicine
Ma. Teresita G. Gabriel, MD, FPDS Dermatology Research Institute for Tropical Medicine

Staphylococcal Infections

Cutaneous Bacterial Infections

Alternative Medicine

Safety and Efficacy of 25% Tinospora rumphii cream vs 2% Mupirocin cream in the treatment of superficial pyodermas caused by S aureus

To compare the bactericidal activity of 25% Tinospora rumphiicream and 2% mupirocin cream based on the percentage of patients bacteriologically cured at day 14 of treatment

To compare the efficacy of 25% Tinospora rumphii cream and 2% mupirocin cream based on the clinical efficacy grading scale of erythema, edema, induration and size of lesions at baseline, days 3, 7 and 14 of treatmentby having a 2 point scale improvement at the end of the treatment period

To compare the Participants Global Assessment score in the 25% Tinospora rumphii cream and 2% mupirocin cream using a 7 point scale at days 3, 7, and 14 of treatment

To compare the occurrence and severity of adverse cutaneous reactions in the 25% Tinospora rumphiicream and 2% mupirocin treatment groups using a 4 point scale on days 3, 7 and 14 of treatment

Completed

Non-clinical Studies

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