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Recapitulations on changes in dengue virus properties and the etiology of dengue hemorrhagic fever.

Author

Related Institution

Department of Parasitology - Institute of Public Health

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Acta Medica Philippina
Frequency
Semi-Annual
Publication Date
January-June 1976
Volume
12
Issue
1
Page(s)
26-32

Abstract

The relation of changes in virus properties and the pathophysiology of dengue hemorrhagic fever is examined in view of previous and present evidences of host-induced modification of virus surface antigens in Aedes albopictus cells. Small (or avirulent) and large (or virulent) plaque variants were assayed in vivo and in vitro; changes in electrophoretic patterns accompanied the transition from virulence to avirulence as well as the alteration in immunological reactivity. Mosquito -adapted virus is not lethal to suckling mice and does not initiate plaque formation in mammalian cells; however, its presence is established by the virus interference test. Host-induced modification or the acquisition of host cell membrane components in the viral coat might predispose to either an abrogation of self-tolerance (an auto-immune process) or to the accummulation is subsequent infections with heterologous dengue virus of antigen-antibody complexes which activate complement and trigger the changes in the blood vascular system that lead to hemorrhagic tendencies. (Summary)

Physical Location

LocationLocation CodeAvailable FormatAvailability
UPM-Med Abstract Print Format
Philippine Council for Health Research and Development Library Fulltext pdf (Request Document)

 
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